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赛宝集团有限公司

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№ CN122940198AInvention
Unknown

单核一价金二卤络合物、其组合物及其制备方法和应用

本发明公开了单核一价金二卤络合物、其组合物及其制备方法和应用，属于医药技术领域。所述络合物具有通式M[AuX]，其中M为药学上可接受的一价阳离子，X为Cl、Br或I。该络合物结构极简、稳定性优异，可穿透血脑屏障等多种组织特异性生理屏障。药效学实验证实，该化合物能同时实现钙稳态重置、异常蛋白解聚、慢性炎症抑制、病理性钙化干预及细胞信号传导功能恢复等多靶点协同作用，显著延长SOD1 G93A ALS转基因小鼠生存期44.5%，安全窗大于300。本发明化合物安全性高、治疗窗宽，可用于制备预防和/或治疗神经退行性疾病、代谢性疾病、恶性肿瘤、慢性疲劳综合征、衰老相关疾病及免疫缺陷等多种疾病的药物。

❖赛宝集团有限公司尚超Oct 20, 2026§ 4/10 ClaimsC01G 7/00 (2006.01), C07C 279/14 (2006.01), C07C 277/08 (2006.01) +15