原始名称记载: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM; THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY

Compositions and methods for ultrasound-induced light generation in the brain (e.g, for use in optogenetic methods) are provided. Mechanoluminescent nanoparticles and liposomes are provided. In some aspects, biocompatible and biodegradable liposomes comprising a sonosensitizer (e.g., IR780) and a chemiluminescent compound (e.g., L012) are provided and can be used, e.g., in combination with focused ultrasound (FUS) to generate light in the brain. Related in vivo and therapeutic methods are also provided.