一种用于治疗骨与软组织肉瘤的树突状细胞疫苗及其制备方法与应用
本发明提供一种用于治疗骨与软组织肉瘤的树突状细胞疫苗及其制备方法与应用,所述树突状细胞疫苗包括由肉瘤细胞裂解物与未成熟树突状细胞共培养得到的成熟树突状细胞。本发明将7种肉瘤细胞的裂解物作为树突状细胞疫苗抗原,解决了现有DC疫苗负载抗原单一的问题,增强抗原递呈和T细胞的活化,激发广泛的免疫反应,减少免疫逃逸,并且不受患者的MHC的类型限制,通用性强,可以使更多患者受益。
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