CARDIAC VALVE WITH EARLY PREFERENTIAL POLARIZATION TOWARDS AN M2 PHENOTYPE POST-IMPLANTATION, AND METHOD OF IMPLANTATION
卷宗概要
发明人
Derrick Johns; Joseph J. Crudden
IPC 分类
CPC 分类
Cardiac replacement valves that are anti-biofilm and tissue-integrating implantable biomaterial devices that optionally can elute therapeutic ions such as magnesium, silver, copper and/or zinc. In certain embodiments, the devices are hydrophilic due to the presence of ceramic particles such as zeolite. In certain embodiments, the devices are subjected to a surface treatment such as a plasma treatment or a corona discharge treatment to enhance the immobilization of integrin-stimulating peptides such as RGD to the biomaterial for cell adhesion enhancement when implanted in a host. Methods of replacing diseased valves in a patient are also disclosed.
原文（中文）
Cardiac replacement valves that are anti-biofilm and tissue-integrating implantable biomaterial devices that optionally can elute therapeutic ions such as magnesium, silver, copper and/or zinc. In certain embodiments, the devices are hydrophilic due to the presence of ceramic particles such as zeolite. In certain embodiments, the devices are subjected to a surface treatment such as a plasma treatment or a corona discharge treatment to enhance the immobilization of integrin-stimulating peptides such as RGD to the biomaterial for cell adhesion enhancement when implanted in a host. Methods of replacing diseased valves in a patient are also disclosed.