NOVEL COATING PROTECTING ACTIVE COMPOUNDS FOR PHARMACEUTICAL, ENZYME, NUTRACEUTICAL, FOOD OR FEED APPLICATIONS
卷宗概要
发明人
Massimiliano Donato Verona; Bindu Lakshmibai Vasanthakumari; Ye Lao
IPC 分类
CPC 分类
The present invention relates to a unique coating comprising a hydrophobic matrix of fatty acids and a water-soluble weak organic acid. During acidic conditions (e.g., pH≤3), the weak organic acid is protonated and is almost insoluble or slowly solubilized, while at neutral to alkaline pH (e.g., pH 6 or higher) it is deprotonated and more easily solubilized, allowing for the release of the active ingredient. All of the materials in the coating are soluble in organic solvents and, preferably, alcohols. In at least one embodiment, the coating is used as an enteric coating. In at least one embodiment, the coating is evenly dispersed without the inclusion of a plasticizer, emulsifier, or emulsifying agent.
原文（中文）
The present invention relates to a unique coating comprising a hydrophobic matrix of fatty acids and a water-soluble weak organic acid. During acidic conditions (e.g., pH≤3), the weak organic acid is protonated and is almost insoluble or slowly solubilized, while at neutral to alkaline pH (e.g., pH 6 or higher) it is deprotonated and more easily solubilized, allowing for the release of the active ingredient. All of the materials in the coating are soluble in organic solvents and, preferably, alcohols. In at least one embodiment, the coating is used as an enteric coating. In at least one embodiment, the coating is evenly dispersed without the inclusion of a plasticizer, emulsifier, or emulsifying agent.