USE OF BENCYCLOQUIDIUM BROMIDE, ISOMER THEREOF AND DERIVATIVE THEREOF IN PREPARATION OF OPHTHALMIC FORMULATION

原文（中文）

The present invention relates to the technical field of medicine, and in particular to a use of bencycloquidium bromide, an isomer thereof and a derivative thereof in the preparation of a drug for preventing or treating an ophthalmic disease. Moreover, the present invention provides an ophthalmic formulation using the bencycloquidium bromide, the isomer thereof and the derivative thereof as active ingredients. According to the present invention, by using the bencycloquidium bromide, the isomer thereof and the derivative thereof in eyes, it is discovered that the bencycloquidium bromide, the isomer thereof and the derivative thereof have an obvious inhibitory effect on changes in ocular axial length and diopter in the progression process of a myopic refractive error, and then it is discovered that the ophthalmic formulation using the bencycloquidium bromide, the isomer thereof and the derivative thereof as active ingredients has significant advantages in the prevention and treatment of ophthalmic diseases, especially in preventing myopia and slowing down the progression of myopia, etc.