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Reagents and Methods for Identifying Pregnancy Risk

发明专利审中
8浏览
21权利要求 · 13 独立
§ Ⅰ

卷宗概要

发明人

Edward E Winger; Jane L Reed

IPC 分类

C12Q 1/6883

CPC 分类

C12Q1/6883C12Q2600/118C12Q2600/158C12Q2600/178

This disclosure relates to miRNA-related reagents and methods for identifying health risks during pregnancy. In preferred embodiments, the miRNAs are selected from those disclosed herein that in a pregnant human being indicate an increased risk of developing a placental bed disorder as compared to the control sample. In some preferred embodiments, such miRNAs are selected from the group consisting of hsa-miR-150-5p, hsa-let-7g-5p, hsa-miR-16-5p, hsa-miR-29a-3p, hsa-let-7f-5p, hsa-miR-15b-5p, hsa-let-7i-5p, hsa-miR-26b-5p, hsa-miR-223-3p, hsa-miR-21-5p, hsa-miR-23a-3p, hsa-miR-142-3p, hsa-miR-19b-3p, hsa-let-7a-5p, hsa-miR-22-3p, hsa-miR-29c-3p, hsa-miR-342-3p, hsa-miR-25-3p, hsa-miR-24-3p, and hsa-miR-17-5p.

原文(中文)

This disclosure relates to miRNA-related reagents and methods for identifying health risks during pregnancy. In preferred embodiments, the miRNAs are selected from those disclosed herein that in a pregnant human being indicate an increased risk of developing a placental bed disorder as compared to the control sample. In some preferred embodiments, such miRNAs are selected from the group consisting of hsa-miR-150-5p, hsa-let-7g-5p, hsa-miR-16-5p, hsa-miR-29a-3p, hsa-let-7f-5p, hsa-miR-15b-5p, hsa-let-7i-5p, hsa-miR-26b-5p, hsa-miR-223-3p, hsa-miR-21-5p, hsa-miR-23a-3p, hsa-miR-142-3p, hsa-miR-19b-3p, hsa-let-7a-5p, hsa-miR-22-3p, hsa-miR-29c-3p, hsa-miR-342-3p, hsa-miR-25-3p, hsa-miR-24-3p, and hsa-miR-17-5p.