PERSONALIZED TUMOR MARKERS
卷宗概要
申请人
Stichting Het Nederlands Kanker Instituut-Antoni van Leeuwenhoek Ziekenhuis; Stichting VU
发明人
Gerrit Albert MEIJER; Evert VAN DEN BROEK; Remondus Johannes Adriaan FIJNEMAN; Sanne ABELN; Soufyan LAKBIR; Jakob HERINGA
IPC 分类
CPC 分类
The invention relates to methods for tumor marker analysis comprising providing a genomic DNA sample from tumor cells of a patient, preselecting a chromosomal region on the genomic DNA comprising at least part of a potential structural variant (SV); and sequencing the genomic region to characterize the potential SV. The invention further relates to methods for detecting minimal residual disease, monitoring treatment response and tumor progression in a patient by employing the SV, and to personalized therapy based on the identity of the SV.
原文（中文）
The invention relates to methods for tumor marker analysis comprising providing a genomic DNA sample from tumor cells of a patient, preselecting a chromosomal region on the genomic DNA comprising at least part of a potential structural variant (SV); and sequencing the genomic region to characterize the potential SV. The invention further relates to methods for detecting minimal residual disease, monitoring treatment response and tumor progression in a patient by employing the SV, and to personalized therapy based on the identity of the SV.