COMPOSITIONS AND METHODS OF USE FOR STABILIZING AND DELIVERY OF ATOMIC LAYER DEPOSITION COATING OF AGENT-CONTAINING LIPID-EMULSION FORMULATIONS

原文（中文）

Embodiments of the present disclosure provide novel compositions and methods for making and using thermostable agent-containing lipid-emulsion formulations. In certain embodiments, compositions and methods are disclosed for adapting lipid nanoemulsions of agent-containing formulations having improved stability and/or retaining or enhancing immunogenicity. In other embodiments, agent-containing lipid-nanoemulsion formulations can be spray-dried and further embedded within glassy matrices or microparticles to improve stability and compatibility with other agents by limiting molecular mobility. In other embodiments, these microparticles harboring essentially dried stabilized agent-containing lipid-emulsion formulations can be coated by one or more coating layer to produce stabilized lipid nanoemulsions of agent-containing formulations. In some embodiments, the coating layer is applied by atomic layer deposition (ALD) and the coating layers include a metalloorganic material.