NOVEL LIPID NANOPARTICLE COMPOSITIONS AND USES THEREOF
卷宗概要
发明人
Bin WU; Heliang SONG; Victoria TRANTOW
IPC 分类
CPC 分类
The present invention provides a lipid nanoparticle (LNP) formulation comprising at least one sialic acid (SA)—containing lipid. The LNP formulation is capable of effectively binding cell surface Siglecs, transfecting certain cells in vitro and targeting certain cells in vivo. The present invention also provides methods of using the LNP compositions described herein for pharmaceutical applications. For example, the LNPs provided herein are useful for the intracellular delivery of a nucleic acid therapeutic to a subject.
原文（中文）
The present invention provides a lipid nanoparticle (LNP) formulation comprising at least one sialic acid (SA)—containing lipid. The LNP formulation is capable of effectively binding cell surface Siglecs, transfecting certain cells in vitro and targeting certain cells in vivo. The present invention also provides methods of using the LNP compositions described herein for pharmaceutical applications. For example, the LNPs provided herein are useful for the intracellular delivery of a nucleic acid therapeutic to a subject.