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NON-SEDATING DEXMEDETOMIDINE TREATMENT REGIMENS

发明专利审中
20权利要求 · 4 独立
§ Ⅰ

卷宗概要

申请人

BioXcel Therapeutics, Inc.

发明人

Vasukumar KAKUMANU; David Christian HANLEY; Frank YOCCA; Chetan Dalpatbhai LATHIA; Lavanya RAJACHANDRAN; Robert RISINGER

IPC 分类

A61K 31/4174A61K 9/A61K 9/6A61K 9/20A61K 9/70A61K 47/10A61K 47/26A61K 47/34A61K 47/38A61K 47/44A61P 25/18A61P 25/20A61P 25/36

CPC 分类

A61K31/4174A61K9/6A61K9/6A61K9/2013A61K9/2018A61K9/7007A61K9/7015A61K47/10A61K47/26A61K47/34A61K47/38A61K47/44A61P25/18A61P25/20A61P25/36

Disclosed herein are methods of administering relatively high doses of dexmedetomidine or a pharmaceutically acceptable salt thereof to a human subject, without also inducing significant sedation. The disclosed methods are particularly suitable for the treatment of agitation, especially when associated with neurodegenerative and/or neuropsychiatric diseases such as schizophrenia, bipolar illness such as bipolar disorder or mania, dementia, depression, or delirium.

原文(中文)

Disclosed herein are methods of administering relatively high doses of dexmedetomidine or a pharmaceutically acceptable salt thereof to a human subject, without also inducing significant sedation. The disclosed methods are particularly suitable for the treatment of agitation, especially when associated with neurodegenerative and/or neuropsychiatric diseases such as schizophrenia, bipolar illness such as bipolar disorder or mania, dementia, depression, or delirium.