Tablet with improved stability
卷宗概要
发明人
Tatsuo NOMURA; Tsubasa KUBO; Toru YASUZAWA
IPC 分类
CPC 分类
A tablet comprising zinc histidine or a solvate thereof as an active ingredient, further comprising one or more ingredients selected from the group consisting of D-mannitol, sucrose, sorbitol, xylitol, corn starch, and potato starch; and crystalline cellulose; and excluding lactose, fructose, and glucose, and a tablet comprising zinc histidine or a solvate thereof as an active ingredient, having a 15-minute dissolution value of 80% or more in the paddle method (test solution: water, rotate speed: 75 rpm) (excluding lactose, fructose, and glucose), obtained by the following steps: granulating zinc histidine or a solvate thereof, one or more components selected from the group consisting of D-mannitol, sucrose, sorbitol, xylitol, corn starch, and potato starch, and crystalline cellulose, with a binder; drying the obtained granulate; and tableting the dried granulate.
原文（中文）
A tablet comprising zinc histidine or a solvate thereof as an active ingredient, further comprising one or more ingredients selected from the group consisting of D-mannitol, sucrose, sorbitol, xylitol, corn starch, and potato starch; and crystalline cellulose; and excluding lactose, fructose, and glucose, and a tablet comprising zinc histidine or a solvate thereof as an active ingredient, having a 15-minute dissolution value of 80% or more in the paddle method (test solution: water, rotate speed: 75 rpm) (excluding lactose, fructose, and glucose), obtained by the following steps: granulating zinc histidine or a solvate thereof, one or more components selected from the group consisting of D-mannitol, sucrose, sorbitol, xylitol, corn starch, and potato starch, and crystalline cellulose, with a binder; drying the obtained granulate; and tableting the dried granulate.