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Heteroaryl compounds as inhibitors of TYK2/JAK1, composition and application thereof

发明专利审中
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23权利要求 · 5 独立
§ Ⅰ

卷宗概要

发明人

Xiaohu Zhang; Sudan He

IPC 分类

C7F 9/6558A61K 31/675A61K 45/6C7F 9/58C7F 9/6509

CPC 分类

C7F9/65583A61K31/675A61K45/6C7F9/58C7F9/650905C7F9/65586

The present disclosure provides phosphonate-containing heterocycle compounds with TYK2/JAK1 inhibitory activities, pharmaceutical compositions comprising the same, and applications thereof. The present disclosure provides compounds of Formula (I), as inhibitors of TYK2/JAK1. These compounds can be used for preventing and/or treating TYK2/JAK1 related diseases and/or conditions without significant inhibition of JAK2 activities.

原文(中文)

The present disclosure provides phosphonate-containing heterocycle compounds with TYK2/JAK1 inhibitory activities, pharmaceutical compositions comprising the same, and applications thereof. The present disclosure provides compounds of Formula (I), as inhibitors of TYK2/JAK1. These compounds can be used for preventing and/or treating TYK2/JAK1 related diseases and/or conditions without significant inhibition of JAK2 activities.