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案件記録

SYNTHETIC RETINOIDS FOR USE IN RAR ACTIVATION

発明審査中
1閲覧数
20請求項 · 5 独立
§ Ⅰ

案件概要

発明者

Andrew Whiting; David Chisholm; Iain Greig; Thabat Khatib; Peter McCaffery

IPC分類

A61K 31/192A61P 25/28C7C 63/74C7C 65/26C7D 213/79C7D 213/80C7D 233/96C7D 241/24C7D 241/38C7D 401/6C12Q 1/48G1N 33/50G1N 33/68

CPC分類

A61K31/192A61P25/28C7C63/74C7C65/26C7D213/79C7D213/80C7D233/96C7D241/24C7D241/38C7D401/6C12Q1/485G1N33/5041G1N33/6893G1N2333/70567

The present invention relates to compounds of formula I: in which A-Aand Rto Rare defined herein, for use in the treatment of a condition or disease which is alleviated by the activation of retinoic acid receptors (RAR). The invention also relates to pharmaceutical compounds comprising such compounds, and related methods of treatment. In an aspect, the invention relates to a method of screening compounds for therapeutic potential in the treatment of a condition or disease which is alleviated by the activation of retinoic acid receptors (RAR). Aspects of the invention relate to novel compounds of formula I in which at least one of Ato Ais N or at least one of Ais CRor Ais CRin which R/Ris halogen.

原文(中国語)

The present invention relates to compounds of formula I: in which A-Aand Rto Rare defined herein, for use in the treatment of a condition or disease which is alleviated by the activation of retinoic acid receptors (RAR). The invention also relates to pharmaceutical compounds comprising such compounds, and related methods of treatment. In an aspect, the invention relates to a method of screening compounds for therapeutic potential in the treatment of a condition or disease which is alleviated by the activation of retinoic acid receptors (RAR). Aspects of the invention relate to novel compounds of formula I in which at least one of Ato Ais N or at least one of Ais CRor Ais CRin which R/Ris halogen.

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