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案件記録

Substituted N-(Pyridin-2-yl)Acetamide Derivatives as CDK12/13 Inhibitors

発明審査中
27請求項 · 9 独立
§ Ⅰ

案件概要

出願人

Aurigene Oncology Limited

発明者

Ramulu Poddutoori; Susanta Samajdar; Subhendu Mukherjee; Suraj Tatyasaheb Gore; Devaraja Thimmasandra Seethappa; Paul Gillespie; Scott Simonovich

IPC分類

A61K 31/675A61K 31/4439A61K 31/444A61K 31/4545A61K 31/496A61K 31/497A61K 31/4995A61K 31/506A61K 31/5377A61K 31/5386C7D 213/75C7D 213/84C7D 401/14C7D 403/14C7D 413/14C7D 451/6C7D 487/8C7D 498/8C7F 9/6558

CPC分類

A61K31/675A61K31/4439A61K31/444A61K31/4545A61K31/496A61K31/497A61K31/4995A61K31/506A61K31/5377A61K31/5386C7D213/75C7D213/84C7D401/14C7D403/14C7D413/14C7D451/6C7D487/8C7D498/8C7F9/65583

The present application provides substituted N-(pyridin-2-yl)acetamide derivatives of formula (I) which are therapeutically useful as CDK12/13 inhibitors. These compounds are useful in the treatment and/or prevention of diseases and/or disorders associated with CDK12/13 in a mammal. In addition, the present application provides preparation of the compounds and pharmaceutical compositions comprising at least one of the substituted N-(pyridin-2-yl)acetamide derivatives of formula (I) or a pharmaceutically acceptable salt, an N-oxide or a stereoisomer thereof.

原文(中国語)

The present application provides substituted N-(pyridin-2-yl)acetamide derivatives of formula (I) which are therapeutically useful as CDK12/13 inhibitors. These compounds are useful in the treatment and/or prevention of diseases and/or disorders associated with CDK12/13 in a mammal. In addition, the present application provides preparation of the compounds and pharmaceutical compositions comprising at least one of the substituted N-(pyridin-2-yl)acetamide derivatives of formula (I) or a pharmaceutically acceptable salt, an N-oxide or a stereoisomer thereof.

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