Method for Synthesizing Amide and/or Polypeptide Using Temporary Protected Amino Acid as Ammonia Component

原文（中国語）

The present disclosure discloses a method for synthesizing an amide and/or a polypeptide using a temporary protected amino acid as an ammonia component. In the present disclosure, a ynamide compound is used as a condensing agent, a low-cost unprotected amino acid is used as the raw material, a silylation reagent is used to temporarily protect the amino acid to perform a condensing reaction, and after the construction of a peptide bond is achieved, a target polypeptide carboxylic acid can be obtained by a simple acid treatment, which can be directly used for the condensation of the next amino acid.