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案件記録

LUBRICIN-LOCALIZED CARTILAGE-LIKE TISSUE, METHOD FOR PRODUCING SAME AND COMPOSITION COMPRISING SAME FOR TREATING ARTICULAR CARTILAGE DAMAGE

発明審査中
6閲覧数
11請求項 · 1 独立
§ Ⅰ

案件概要

発明者

Noriyuki TSUMAKI; Yoshiaki TAKEI

IPC分類

C12N 5/77A61L 27/22A61L 27/38C12M 1/6

CPC分類

C12N5/655C12M27/2A61L27/227A61L27/3852C12N2500/30C12N2501/15C12N2501/155C12N2501/19C12N2506/2C12N2506/45C12N2527/

A lubricin-localized cartilage-like tissue and a method for producing the same, wherein, when in an arbitrary cross section passing a first center of mass of a cartilage-like tissue derived from pluripotent stem cells or a center-of-mass region, which is a portion inside a concentric sphere being centered at the first center of mass and having a diameter of [first major diameter×0.2], the expression level of lubricin per unit area contained in a central region, which is a portion inside a concentric circle being centered at a second center of mass that is the center of mass of the cross section and having a diameter of [major diameter of cross section (second major diameter)×(0.4 to 0.9)] is referred to as the central lubricin level and the expression level of lubricin per unit area contained in the non-central region is referred to as the non-central lubricin level.

原文(中国語)

A lubricin-localized cartilage-like tissue and a method for producing the same, wherein, when in an arbitrary cross section passing a first center of mass of a cartilage-like tissue derived from pluripotent stem cells or a center-of-mass region, which is a portion inside a concentric sphere being centered at the first center of mass and having a diameter of [first major diameter×0.2], the expression level of lubricin per unit area contained in a central region, which is a portion inside a concentric circle being centered at a second center of mass that is the center of mass of the cross section and having a diameter of [major diameter of cross section (second major diameter)×(0.4 to 0.9)] is referred to as the central lubricin level and the expression level of lubricin per unit area contained in the non-central region is referred to as the non-central lubricin level.

外部リソース