Functionalized Conjugation Crosslinkers and Uses Thereof
Functionalized Conjugation Crosslinkers and Uses Thereof
The present invention relates to multi-functionalized crosslinker compounds with a protected aminooxy group and a N-hydroxysuccinimide ester (NHS) activated carbonyl group. The crosslinkers may form conjugates of biomolecules (e.g., antibodies, oligonucleotides, lipids) with each other or with small molecules. The resulting conjugates may have applications in various therapeutic areas, such as, for example, cancers, infectious disease autoimmune disorders, neurodegenerative disease, etc., diagnostic areas and drug delivery. The crosslinkers may also be used to functionalize the surface of various materials such as, for example, metals, nanoparticles, etc. with biological molecules and small molecules, which may be useful in various diagnostic, therapeutic and drug delivery technologies.