METHOD AND APPARATUS FOR HIGH-FIDELITY LENSLESS MULTIMODE FIBER-BASED PHOTOACOUSTIC ENDOMICROSCOPY

원문 (중국어)

A method and implementing apparatus for high-fidelity lensless multimode fiber-based photoacoustic endomicroscopy. The method includes an improved nonconvex optimization method to achieve non-interferometric calibration of multimode optical fiber that is used for laser scanning imaging. Before imaging, the complex-valued transmission matrix is quickly reconstructed directly from the multimode fiber output intensity measurement without the need for a reference beam. During imaging, wavefront shaping technology is used to perform high-speed laser scanning at the end of the multimode fiber, which excites photoacoustic signals on tissues. The photoacoustic signals are detected in a non-focused manner by a high-sensitivity fiber-optic-ultrasonic-sensor outside the sample. The implementing apparatus includes a wavefront shaping module, a fiber imaging probe, and a photoacoustic signal acquisition and processing module.