NOVEL LIPID NANOPARTICLE COMPOSITIONS AND USES THEREOF
개요
발명자
Bin WU; Heliang SONG; Victoria TRANTOW
IPC 분류
CPC 분류
The present invention provides a lipid nanoparticle (LNP) formulation comprising at least one sialic acid (SA)—containing lipid. The LNP formulation is capable of effectively binding cell surface Siglecs, transfecting certain cells in vitro and targeting certain cells in vivo. The present invention also provides methods of using the LNP compositions described herein for pharmaceutical applications. For example, the LNPs provided herein are useful for the intracellular delivery of a nucleic acid therapeutic to a subject.
원문 (중국어)
The present invention provides a lipid nanoparticle (LNP) formulation comprising at least one sialic acid (SA)—containing lipid. The LNP formulation is capable of effectively binding cell surface Siglecs, transfecting certain cells in vitro and targeting certain cells in vivo. The present invention also provides methods of using the LNP compositions described herein for pharmaceutical applications. For example, the LNPs provided herein are useful for the intracellular delivery of a nucleic acid therapeutic to a subject.