ENGINEERED IMMUNE CELLS WITH ENHANCED POTENCY AND USES OF SAME IN IMMUNOTHERAPY

원문 (중국어)

Several embodiments of the methods and compositions disclosed herein relate to immune cells that are engineered to express chimeric antigen receptors as well as genetically edited or otherwise engineered enhance the persistence the cells in immunotherapy. In several embodiments, the cells are edited to knock out a target gene that encodes a protein involved in antigen processing and presentation by major histocompatibility complex class I molecules. In several embodiments, a mixture of immune cell types is used, optionally in allogeneic therapy. The engineering and editing of the cells, such as NK cells and/or T cells exhibit enhanced cytotoxicity and/or persistence, as well as reduced risk of reduced graft versus host, host versus graft, and graft versus graft effects.