ULTRASOUND OPTOGENETIC COMPOSITIONS AND METHODS
개요
출원인
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM; THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
발명자
Huiliang WANG; Wenliang WANG; Kai Wing Kevin TANG; Guosong HONG; Xiang WU
IPC 분류
CPC 분류
Compositions and methods for ultrasound-induced light generation in the brain (e.g, for use in optogenetic methods) are provided. Mechanoluminescent nanoparticles and liposomes are provided. In some aspects, biocompatible and biodegradable liposomes comprising a sonosensitizer (e.g., IR780) and a chemiluminescent compound (e.g., L012) are provided and can be used, e.g., in combination with focused ultrasound (FUS) to generate light in the brain. Related in vivo and therapeutic methods are also provided.
원문 (중국어)
Compositions and methods for ultrasound-induced light generation in the brain (e.g, for use in optogenetic methods) are provided. Mechanoluminescent nanoparticles and liposomes are provided. In some aspects, biocompatible and biodegradable liposomes comprising a sonosensitizer (e.g., IR780) and a chemiluminescent compound (e.g., L012) are provided and can be used, e.g., in combination with focused ultrasound (FUS) to generate light in the brain. Related in vivo and therapeutic methods are also provided.