Method for Synthesizing Amide and/or Polypeptide Using Transient Protected Amino Acid as Ammonia Component
개요
발명자
Junfeng Zhao; Penghui Wang; Tao Liu
IPC 분류
CPC 분류
The present disclosure discloses a method for synthesizing an amide and/or a polypeptide using a transient protected amino acid as an ammonia component. In this method, an allenone compound is used as a condensing reagent, and a silylation reagent is used to temporarily protect the carboxyl of an amino acid or peptide fragment with amino and carboxyl groups both unprotected first. Then after forming an amide bond with another molecular carboxylic acid or amino acid or α-carbonyl alkenyl ester derivative of the C-terminal carboxyl of the polypeptide, the temporarily protected carboxyl is deprotected on site under an acidic condition to obtain a target carboxylic acid product and to cyclicly build new peptide bonds.
원문 (중국어)
The present disclosure discloses a method for synthesizing an amide and/or a polypeptide using a transient protected amino acid as an ammonia component. In this method, an allenone compound is used as a condensing reagent, and a silylation reagent is used to temporarily protect the carboxyl of an amino acid or peptide fragment with amino and carboxyl groups both unprotected first. Then after forming an amide bond with another molecular carboxylic acid or amino acid or α-carbonyl alkenyl ester derivative of the C-terminal carboxyl of the polypeptide, the temporarily protected carboxyl is deprotected on site under an acidic condition to obtain a target carboxylic acid product and to cyclicly build new peptide bonds.