SYNTHETIC HEXASACCHARIDES MIMICS OF HEPARIN SHOWING HEPARANASE INHIBITION ACTIVITY
개요
출원인
CENTRO ALTA TECNOLOGIA ISTITUTO DI RICERCHE CHIMICHE E BIOCHIMICHE G. RONZONI S.R.L.
발명자
Annamaria NAGGI; Maurice PETITOU; Ming Hong NI
IPC 분류
CPC 분류
The present invention is directed to hexasaccharides mimetics of heparins presenting remarkable heparanase inhibition activity. The compounds have formula (I), wherein Ris selected from the group consisting of NH, NHSONa, NHAc; Ris selected from the group consisting of NH, NHSONa, NHAc; Ris selected from the group consisting of Bn, H; Ris selected from the group consisting of Ac, H, SONa; Ris CONa; Ris selected from the group consisting of Me, Ethyl, Alkyl, alkyl azide, alkynyl, cholestanol aglycon; Ris selected from the group consisting of CHOH, COOH.
원문 (중국어)
The present invention is directed to hexasaccharides mimetics of heparins presenting remarkable heparanase inhibition activity. The compounds have formula (I), wherein Ris selected from the group consisting of NH, NHSONa, NHAc; Ris selected from the group consisting of NH, NHSONa, NHAc; Ris selected from the group consisting of Bn, H; Ris selected from the group consisting of Ac, H, SONa; Ris CONa; Ris selected from the group consisting of Me, Ethyl, Alkyl, alkyl azide, alkynyl, cholestanol aglycon; Ris selected from the group consisting of CHOH, COOH.