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기록

SIRNA TARGETING AND REGULATING PCSK9 GENE EXPRESSION AND USE THEREOF

발명심사 중
28청구항 · 10 독립항
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개요

발명자

Gengshen SONG; Zeao HUANG; Shuo YANG; Zhikang TIAN; Yucheng WU; Peng YAO; Xiaowen YU; Dawei HUANG; Xue PANG; Fang LIN

IPC 분류

C12N 15/113A61P 3/6

CPC 분류

C12N15/1137A61P3/6C12N2310/11C12N2310/14C12N2310/312C12N2310/321C12N2310/322C12N2310/351C12Y304/21061

The present disclosure relates to siRNAs that target and regulate PCSK9 gene expression and use thereof. Experimental results show that some alternately modified and specific template-modified oligonucleotide sequences can significantly inhibit PCSK9 expression and can be used to develop drugs to treat PCSK9-related diseases.

원문 (중국어)

The present disclosure relates to siRNAs that target and regulate PCSK9 gene expression and use thereof. Experimental results show that some alternately modified and specific template-modified oligonucleotide sequences can significantly inhibit PCSK9 expression and can be used to develop drugs to treat PCSK9-related diseases.