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LACHNOSPIRACEAE SP. CAS12A MUTANTS WITH ENHANCED CLEAVAGE ACTIVITY AT NON-CANONICAL TTTT PROTOSPACER ADJACENT MOTIFS
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20Claims · 2 independent
§ Ⅰ
Dossier Overview
Applicant
INTEGRATED DNA TECHNOLOGIES, INC.
Inventor
Liyang Zhang; Christopher Anthony Vakulskas
IPC Classification
C12N 9/22
CPC Classification
C12N9/22
Described herein are CAS12A mutants from Lachnospiraceae bacterium and methods for use thereof. These mutants have enhanced DNA cleavage activities at non-canonical TTTT protospacer adjacent motifs (PAM) compared to the wild-type enzyme.
Original (Chinese)
Described herein are CAS12A mutants from Lachnospiraceae bacterium and methods for use thereof. These mutants have enhanced DNA cleavage activities at non-canonical TTTT protospacer adjacent motifs (PAM) compared to the wild-type enzyme.
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