原始名称记载: Ohio State Innovation Foundation

A smoking machine adaptor device including a base configured to couple to a smoking machine, the base defining a central axis and a base cavity, a cap including a cap flange defining a cap aperture, and a cap actuator coupled to the base and configured to move the cap flange relative to the base along the central axis between a first position to a second position, and a resiliently deformable ferrule sized to be received within the base cavity and defining a ferrule aperture aligned axially with the cap aperture along the central axis. The ferrule aperture defines a. first ferrule area in a plane perpendicular to the central axis when the cap flange is in the first position, a. second, smaller ferrule area in the plane perpendicular to the central axis when the cap flange is in the second position.

Described herein are sensors for detecting an analyte of interest in a sample. These sensors can comprise a potentiometric sensor comprising a surface functionalized with a pH-sensitive aptamer switch that specifically binds the analyte of interest, wherein the pH-sensitive aptamer switch is operatively coupled to the potentiometric sensor such that binding of the analyte of interest by the pH-sensitive aptamer switch induces a measurable change in the potentiometric sensor; and an auxiliary electrode in proximity to the surface, wherein the electrode is configured to alter a pH of a microenvironment in contact with the surface, thereby reversibly shuttling the pH-sensitive aptamer switch between a first state wherein it specifically binds the analyte of interest and a second state wherein it does not specifically bind the analyte of interest.