SYNTHETIC HEXASACCHARIDES MIMICS OF HEPARIN SHOWING HEPARANASE INHIBITION ACTIVITY
卷宗概要
申请人
CENTRO ALTA TECNOLOGIA ISTITUTO DI RICERCHE CHIMICHE E BIOCHIMICHE G. RONZONI S.R.L.
发明人
Annamaria NAGGI; Maurice PETITOU; Ming Hong NI
IPC 分类
CPC 分类
The present invention is directed to hexasaccharides mimetics of heparins presenting remarkable heparanase inhibition activity. The compounds have formula (I), wherein Ris selected from the group consisting of NH, NHSONa, NHAc; Ris selected from the group consisting of NH, NHSONa, NHAc; Ris selected from the group consisting of Bn, H; Ris selected from the group consisting of Ac, H, SONa; Ris CONa; Ris selected from the group consisting of Me, Ethyl, Alkyl, alkyl azide, alkynyl, cholestanol aglycon; Ris selected from the group consisting of CHOH, COOH.
原文（中文）
The present invention is directed to hexasaccharides mimetics of heparins presenting remarkable heparanase inhibition activity. The compounds have formula (I), wherein Ris selected from the group consisting of NH, NHSONa, NHAc; Ris selected from the group consisting of NH, NHSONa, NHAc; Ris selected from the group consisting of Bn, H; Ris selected from the group consisting of Ac, H, SONa; Ris CONa; Ris selected from the group consisting of Me, Ethyl, Alkyl, alkyl azide, alkynyl, cholestanol aglycon; Ris selected from the group consisting of CHOH, COOH.