一类2,4-二氨基嘧啶-6-芳杂环嘧啶类化合物及其应用
本发明公开了一类2,4‑二氨基嘧啶‑6‑芳杂环嘧啶类化合物及其应用,2,4‑二氨基嘧啶‑6‑芳杂环嘧啶类化合物具有如下结构通式:;其中:W,X,Y和Z各自独立地选自氢或氮。本发明设计合成的2,4‑二氨基嘧啶‑6‑芳杂环嘧啶类化合物是一类新型的NF‑κB诱导激酶(NIK)抑制剂,适合于以NIK为靶点的药物开发,得到的药物可用于治疗白血病和多发性骨髓瘤胶质瘤等恶性肿瘤。
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