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金花企业（集团）股份有限公司西安金花制药厂

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№ CN122973633AInvention
Unknown

一种用于改善金天格胶囊中人工虎骨粉性能的复合辅料及金天格胶囊

本发明一种用于改善金天格胶囊中人工虎骨粉性能的复合辅料及金天格胶囊，其中复合辅料由微硅胶、微晶纤维素和乳糖组成。以人工虎骨粉的总重量计，所述微硅胶的用量为0.1%～0.5%，所述微晶纤维素的用量为5%～12%，所述乳糖的用量为5%～12%。通过将微硅胶、微晶纤维素、乳糖等多种功能互补的辅料组合使用，实现了显著的协同效应，协同系数达1.45。采用本发明的复合辅料，人工虎骨粉流动函数FF提升125.51%，分散度降低66.88%，均一性CV降低45.43%，效果显著优于单一辅料方案（FF提升仅65.01%）。本发明通过微硅胶、微晶纤维素、乳糖三重机制的协同作用，从根本上改善了人工虎骨粉的流动性和均一性。

❖陕西中医药大学; 金花企业（集团）股份有限公司西安金花制药厂邹俊波; 史亚军; 袁普卫; 刘园娟; 李钤Oct 27, 2026§ 4/10 ClaimsA61K 47/38 (2006.01), A61K 47/26 (2006.01), A61K 47/02 (2006.01) +3