CNIPA.AI
Sign In

All tools

Patent applicant records

APPLICANTS

湖南医药学院

Browse source applicant names and unchanged name fields from imported patent records.

These are name-based results, not verified legal entities. Identical names may refer to different people or organizations; aliases and historical names are not merged.

This name was extracted from a distinct applicant node in the source XML.

1 indexed patent records

Patent counts refer to distinct records held by this site, not an applicant’s complete portfolio. A joint name field is not a single company.

Verified corpus date coverage and last import time are not currently available. Publication dates on patent records are not import dates. Cached directory results may lag behind new imports.

Search the local original applicant field containing this full text. Results may include joint lists or longer names; this is not an exact identity search.

Search patents with this applicant condition
Open patent writing
№ CN122937223AInvention
Unknown

TET2基因在预防和/或治疗动脉粥样硬化中的应用

本发明涉及生物医药技术领域，公开了上调TET2基因表达水平和/或提高TET2蛋白表达水平的物质在制备预防和/或治疗动脉粥样硬化药物中的应用。本发明发现，氧化三甲胺（TMAO）可促进动脉粥样硬化形成，诱导血管内皮细胞线粒体功能障碍及焦亡，并降低TET2蛋白表达水平。通过上调TET2基因表达和/或提高TET2蛋白表达水平，可改善血管内皮细胞线粒体稳态，降低线粒体活性氧水平，抑制NLRP3炎性小体活化及caspase‑1/GSDMD介导的细胞焦亡，同时降低ICAM‑1和VCAM‑1表达，减轻血管内皮细胞炎症活化。本发明为TMAO相关动脉粥样硬化的防治提供了新的分子靶点和治疗策略。

❖湖南医药学院陈金娜; 张建武; 危当恒; 袁鼎晶; 易瑜蕾Oct 20, 2026§ 3/10 ClaimsA61K 45/00 (2006.01), A61P 9/10 (2006.01), A61K 38/44 (2006.01) +4