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Original name record: 安徽中医药大学; 亳州学院

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1 indexed patent records

№ CN121378376AInvention
Active

一种蟾毒内酯类化合物衍生物及其制备方法和应用

本发明属于药物合成技术领域，特别涉及一种蟾毒内酯类化合物衍生物及其制备方法和应用。本发明提供的蟾毒内酯类化合物衍生物的结构式如式（Ⅰ）所示。其是以含有14,15位环氧环的蟾蜍内酯类化合物为原料，经开环得到14位羟基，15位碱性基团（含N杂环、脂肪胺或芳香胺）的一系列结构化合物，对Huh‑7、HN4和HEP G2的IC抑制浓度显著低于以蟾毒灵为代表的蟾蜍内酯类化合物，具有优异的抑制肝癌细胞或喉鳞癌细胞增殖作用，有望开发为抗肝癌或抗喉鳞癌新药。

❖安徽中医药大学; 亳州学院吴德玲; 张伟; 左亚锋; 彭灿; 高波; 陈仕云§ 4/10 ClaimsC07J 41/00 (2006.01), C07J 43/00 (2006.01), A61K 31/585 (2006.01) +33