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№ CN122983267AInvention

Unknown

采用离子色谱检测新型类肝素海洋药物溶出度的方法

本发明提供了采用离子色谱检测新型类肝素海洋药物溶出度的方法，涉及药物检测领域，包括：称取聚甘露糖醛酸丙酯硫酸钠对照品制备对照品溶液；取1片供试品，溶解得到供试品溶出液；取溶出液，过滤并弃去初滤液，取续滤液为供试品溶液；设置离子色谱仪检测条件：选择聚合物基质阳离子色谱柱，检测器为抑制电导检测器，设置淋洗液进料流量、柱温、检测器温度；分别将对照品溶液与供试品溶液注入离子色谱仪，记录色谱图中的峰面积，根据对照品溶液和供试品溶液的峰面积，确定聚甘露糖醛酸丙酯硫酸钠片的溶出度。本发明采用离子色谱仪，检测聚甘露糖醛酸丙酯硫酸钠中的钠元素来计算溶出度，克服现有检测方法重现性不佳，检测精密度不理想的问题。

❖南京佰麦生物技术有限公司蒋玉伟; 李浩冬; 施嘉玲Oct 27, 2026§ 1/10 ClaimsG01N 30/02 (2006.01), G01N 30/06 (2006.01), G01N 30/14 (2006.01) +8

№ CN122911915AInvention

Unknown

一种克拉霉素无缝软胶囊及其制备方法

本发明公开一种自乳化的克拉霉素新型软胶囊及其制备方法，属于药物制剂技术领域。现有克拉霉素口服片剂、胶囊剂型溶出速率慢、生物利用度较低，颗粒剂、分散片等剂型味道极苦，儿童患者用药依从性差。本发明创新性地采用自乳化药物递送系统制备软胶囊内容物，并搭配无缝软胶囊滴制成型技术，成功解决克拉霉素口服给药难题，显著提高生物利用度，并可按照儿童体重精准、“无痛”给药。本技术制备工艺简单可控，适合大规模工业化生产，具有极高的经济和社会价值。

❖南京佰麦生物技术有限公司蒋玉伟; 李浩冬; 林元节; 王宏响Oct 16, 2026§ 2/10 ClaimsA61K 9/48 (2006.01), A61K 31/7048 (2006.01), A61K 9/107 (2006.01) +6