使用重组多肽用于癌症治疗的方法和组合物
本文公开了用于治疗人对象的癌症的方法,该方法包括施用包含癌症特异性CD8+ T细胞表位的重组多肽。由主要组织相容性复合体(MHC)分子识别的肽可以在对象中激活对靶癌细胞的T细胞免疫应答。本公开还提供在对象中限制于由特异性HLA‑等位基因表达的MHC分子的癌症特异性CD8+ T细胞表位。本公开还提供编码重组多肽的组合物,其能够引发膨胀记忆CD8+ T细胞应答。
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