一种腈水解酶突变体及其应用
本发明公开了一种腈水解酶突变体及其应用。所述腈水解酶的氨基酸序列相对SEQ ID NO:1包含T197S氨基酸残基的差异;所述腈水解酶突变体与氨基酸序列如SEQ ID NO:1所示的野生型腈水解酶相比提高了产物中2‑吡啶甲酰胺的含量。本发明所述的腈水解酶突变体与野生型酶催化2‑氰基吡啶的转化率相当,产物中的2‑吡啶甲酰胺含量显著提高,产物中2‑吡啶甲酰胺的占比最高可达100%,大大提高了2‑吡啶甲酰胺的合成率。
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