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Original name record: 上海交通大学; 上海交通大学深圳研究院

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№ CN121313666AInvention
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用于辅助细胞移植的长效释氢体系及其制备方法和应用

用于辅助细胞移植的长效释氢体系及其制备方法和应用，本发明域及医疗技术领域，为提供一种能向细胞移植部位进行靶向递送并持续释放高剂量H的物质，本发明的提供一种用于辅助细胞移植的长效释氢体系，所述的长效释氢体系包括有粒径为5nm‑10μm的释氢材料、水凝胶基质，所述的细胞分散在体系中；所述的释氢材料浓度为0.01‑100μg/mL，所述的细胞含量为10000‑100000000细胞/mL。述的长效释氢体系用于在体外分化/成球过程中维持移植细胞的活力和定向分化以及在移植后的病理微环境下维持移植细胞活性和特性。在恶性病理微环境中，本发明通过持续供给氢气，有效维持干细胞球组装/分化成为软骨细胞微球的活性和透明软骨表型，持续供给氢气来维持移植干细胞的活性与透明软骨分化潜力，以及持续供给氢气来维持移植软骨细胞的活性与透明特性。

❖上海交通大学; 上海交通大学深圳研究院何前军; 陈胜强; 夏超; 丁文江§ 1/10 ClaimsA61K 33/00 (2006.01), A61K 33/24 (2019.01), A61K 33/26 (2006.01) +16