元の名称記録: University of Kentucky Research Foundation

A compound is provided that is a modified piperidinyl urea-based inhibitors of DCN1-UBE2M interaction, abridged or unbridged NAcM-OPT derivative compound, or a bridged and unbridged isoquinoline carboxamide derivative compound, or a pharmaceutically acceptable salt thereof. A pharmaceutical composition comprising the compound, or a pharmaceutically acceptable salt thereof, is provided. Methods for treating diseases or disorders characterized by uncontrolled cellular proliferation are described including administering the compound, pharmaceutically acceptable salt thereof, or pharmaceutical composition comprising the compound or pharmaceutically acceptable salt thereof to a subject in need thereof.

Certain aspects of the disclosure provide a method for performing backup operations in a computing environment. The method may include: performing a depth-restricted find operation on a file system to identify directories for backup; generating a list of potential backup jobs by analyzing the identified directories and determining a backup type for each directory; sorting the list of potential backup jobs based on at least one of criticality, file size, or historical backup performance; randomizing the sorted list of backup jobs while maintaining critical job ordering requirements; determining resource requirements for each backup job, including memory usage, CPU utilization, and network bandwidth consumption; creating a backup schedule by matching backup jobs to available system resources; and executing the backup jobs according to the backup schedule, while dynamically adjusting the schedule based on real-time resource availability.