含有抗体诱导型结构域的嵌合抗原受体
本公开涉及包含细胞外辅助结构域的嵌合抗原受体(CAR),表达所述CAR的T细胞可以通过所述细胞外辅助结构域以抗原非依赖性方式被激活。具体而言,本公开的所述CAR的所述细胞外辅助结构域是能够被抗体或包含其抗原结合片段的多肽结合的抗体诱导型结构域。这样,表达所述CAR的T细胞能够通过所述抗体与所述抗体诱导型结构域的结合被激活。
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