一种Ac-SDKP-PEVs载药系统的构建方法和应用
本发明中公开了一种Ac‑SDKP‑PEVs载药系统的构建方法和应用,属于生物医药技术领域。本发明以PEVs作为仿生纳米递送载体,采用Ac‑SDKP的C末端聚组氨酸标签与胆固醇锚定策略,将Ac‑SDKP构建为Ac‑SDKP‑His6‑CHOL衍生物并负载于PEVs上,形成Ac‑SDKP‑PEVs载药系统,使抗炎四肽获得更高载药效率、较稳定的纳米尺度、低促炎风险及增强的内皮抗炎效果。
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