一种靶向CD19的CAR-γδT细胞及其制备方法和用途
本发明公开了一种靶向CD19的CAR‑γδT细胞及其制备方法和用途,属于生物医疗技术领域。本发明提供了一种靶向CD19的CAR‑γδT细胞,能够有效识别并杀伤CD19阳性肿瘤细胞。本发明CAR‑γδT细胞在体外和体内均表现出良好的抗肿瘤效果,为急性淋巴细胞白血病、非霍奇金淋巴瘤等CD19阳性肿瘤提供了非人类白细胞抗原依赖、天然免疫增强和广谱肿瘤杀伤的新型免疫治疗策略,具备良好的应用前景。
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