用于鉴定和选择用于生物医学应用的自我复制RNA分子的方法
本公开文本总体上涉及鉴定和/或选择适用于生物医学应用的自我复制RNA(srRNA)递送系统的方法。更特别地,本公开文本涉及使用srRNA疫苗和生物治疗剂的关键质量属性的组合来鉴定和/或选择srRNA递送系统的方法。还提供了srRNA组合物、通过本公开文本的方法获得的配制品、以及用于在有需要的受试者中诱导药效学作用的方法、以及用于预防和/或治疗各种健康状况的方法。
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