一种新型放射性标记的氘代去甲肾上腺素类似物
本发明提供了一种新型的放射性核素标记的氘代去甲肾上腺素类似物及其制备方法、药物组合物及其应用。本发明提供的放射性核素标记的氘代去甲肾上腺素类似物具有如式Ⅰ的结构及其前体具有如式Ⅱ的结构,可被用于诊断和/或治疗神经内分泌肿瘤,具有较好的靶向亲和力和较高的体外稳定性,可被大量摄取进入肿瘤细胞而蓄积在肿瘤病灶处,较为优选的氘代化合物相较于未氘代化合物表现出骨骼积累减少,肿瘤摄取增加,从而提高对患者的诊断能力。
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