在抗原特异性免疫细胞中调节CD160功能的方法及其用途
本发明提供了表达外源CD160蛋白质的修饰的抗原特异性免疫细胞。在一些实施方式中,修饰的抗原特异性免疫细胞进一步包括功能性外源受体,比如工程化的TCR或CAR。本发明还提供了调节抗原特异性免疫细胞中CD160活性的方法。本发明还提供了使用本文所述的修饰的抗原特异性免疫细胞和CD160活性的调节剂治疗癌症的方法和药物组合物。
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