一种防治牛支原体感染的免疫原性组合物及其应用
本发明涉及一种新的预防和治疗牛支原体感染的融合蛋白、免疫原性组合物、重组疫苗,以及分子架构设计和应用。本发明提供了新的融合蛋白分子架构,其包含Bmp、FBA两种基因编码的融合蛋白,或EF‑Tu、DnaK、EF‑G三种基因编码的融合蛋白,可用于核酸疫苗或亚单位疫苗的研发。本发明的融合分子具有良好的免疫原性,提供有效的免疫保护效果,且在部分个体中可以清除牛支原体定植,可用于牛支原体感染疾病防治,具有广阔的畜牧业应用前景。
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