VAV1降解剂
本发明公开了一种通式(I‑1)或式(I‑2)所示的VAV1降解剂,其药物组合物、制备方法及其在制备、预防和/或治疗自身免疫性疾病和炎症适应症的药物的用途。发明所提供的化合物具有较好的VAV1降解活性,可通过加强VAV1蛋白与E3连接酶的相互作用,增强VAV1蛋白的降解,可用于治疗和/或预防与VAV1相关的各种疾病,特别是自身免疫性疾病和肿瘤的治疗。
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