一种依西美坦EP药典C杂的制备方法
本发明公开了一种依西美坦EP药典C杂的制备方法,所述制备方法使用低成本中间体作为起始物料,使用常见的甲醛水溶液和对甲苯磺酸以及酶催化反应,减少高毒性高危害试剂,减少副反应;升温加压一步完成6位、16位亚甲基结构构建,减少后处理工作量,减少后续纯化难度,提高收率,对于依西美坦的质量控制具有显著意义。
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