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4.1R蛋白作为多发性骨髓瘤CD40/NF-κB信号通路抑制剂及药物的应用
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10Claims · 2 independent
§ Ⅰ
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Inventor
梁桃桃; 周言言; 刘登辉; 邵奇; 潘丹; 郭钰莹
IPC Classification
A61K 38/16 (2006.01)A61P 35/00 (2006.01)A61P 7/00 (2006.01)
本发明涉及一种4.1R蛋白作为多发性骨髓瘤CD40/NF‑κB信号通路抑制剂及药物的应用，属于生物医药技术领域。4.1R的FERM和CTD结构域与CD40相互作用，并与NF‑κB p50形成复合物，从而在CD40/NF‑κB轴中充当支架蛋白，抑制异常的NF‑κB激活，进而抑制CD40/NF‑κB信号通路，发挥抗癌作用。
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