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一种抗体药物偶联物及其制备方法与用途
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13Claims · 6 independent
§ Ⅰ
Dossier Overview
Inventor
王嘉恒; 李大伟
IPC Classification
A61K 47/68 (2017.01)A61K 47/65 (2017.01)A61K 38/16 (2006.01)A61P 35/00 (2006.01)
本申请涉及生物医药技术领域，特别是涉及一种抗体药物偶联物及其制备方法与用途。所述抗体药物偶联物，以蛋白毒性小分子蓖麻毒素A链替代传统化学毒素，降低了系统性毒副作用。并且所述抗体药物偶联物通过基因重组与定点酶切连接策略进行制备，有效保障了产物一致性、工艺稳定性及可放大性。所获得的抗体药物偶联物展现出优异的肿瘤抑制生物活性。
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