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DNA聚合酶θ与细胞程序性死亡-配体1双靶点抑制剂及其制备方法和医药用途

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10Claims · 8 independent
§ Ⅰ

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Applicant

中国药科大学; 骆国顺

Original name record: 中国药科大学; 骆国顺 · View all patentsPatent applicant records

Inventor

骆国顺; 向华; 黎健誉; 杨瑾越

IPC Classification

C07D 417/12 (2006.01)C07D 417/14 (2006.01)A61P 35/00 (2006.01)A61P 1/00 (2006.01)A61P 15/14 (2006.01)A61P 15/00 (2006.01)A61P 1/18 (2006.01)A61K 31/4439 (2006.01)A61K 31/4545 (2006.01)A61K 31/444 (2006.01)A61K 31/496 (2006.01)

本发明公开了DNA聚合酶θ（Polθ）与细胞程序性死亡‑配体1（PD‑L1）双靶点抑制剂及其制备方法和医药用途。本发明的化合物如通式（I）所示，可同时靶向Polθ与PD‑L1，发挥抑制Polθ与PD‑L1的双重作用，可用于制备治疗同源重组修复途径（HR）缺陷型癌症的药物。(I)。

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