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一种产米卡芬净前体FR901379的重组基因工程菌及应用
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10Claims · 3 independent
§ Ⅰ
Dossier Overview
Inventor
柳志强; 陶芳婷; 周海岩; 郭佳琪; 朱文静; 郑裕国
IPC Classification
C12N 1/15 (2006.01)C12N 15/80 (2006.01)C12N 15/54 (2006.01)C12N 15/55 (2006.01)C12P 21/04 (2006.01)C12R 1/645 (2006.01)
本发明公开了一种产米卡芬净前体FR901379的重组基因工程菌及应用，重组基因工程菌是在鞘茎点霉基因组中过表达表观遗传修饰因子，筛选获得高产米卡芬净前体FR901379的重组基因工程菌；所述表观遗传修饰因子包括组蛋白甲基转移酶、组蛋白甲基转移酶或组蛋白去乙酰化酶。所述工程菌株生产FR901379的产量较原始菌株提高40%。本发明所述方法具有操作简便、转化效率高、遗传稳定性好的特点。
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